Rogel Cancer Center at AACR 2025

8-9:30 a.m.: Room S406 Vista Ballroom – McCormick Place South Level 4
Session ED08 - Chemistry to the Clinic Part 1 of 3: Expanding the Therapeutic Window of Antibody Drug Conjugates in Cancer
Greg Thurber, Chair

9-9:20 a.m.: Room S406 Vista Ballroom – McCormick Place South Level 4
Design of novel antibody drug conjugates and ADC combinations to maximize the therapeutic window
Greg Thurber

3-5:15 p.m.: Location TBA
MS.PS01.01 - The Impact of Disparities and Lifestyle Choices on Cancer Risks and Outcomes
Alison M. Mondul, Co-Chair

3:30-4:30 p.m.: Spotlight Theater E South Hall A Unraveling tumor complexity with signalStar® multiplex IHC and inTraSeq™ single cell analysis: antibody-based approaches in spatial biology and scRNA-seq
Dafydd G. Thomas

3:55-4:10 p.m.: Location TBA
1140 - Digital twins for in vivo metabolic flux estimations in brain cancer patients
Baharan Meghdadi, Wajd N. Al-Holou, Andrew J. Scott, Anjali Mittal, Ningning Liang, Sravya Palavalasa, Abhinav Achreja, Nathan Qi, Alexandra O'Brien, Vijay Tarnal, Weihua Zhou, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl, Deepak Nagrath

4:10-4:25 p.m.: Location TBA
1148 - Longitudinal monitoring of circulating tumor cell burden and single-cell RNA profiling in ALK-positive NSCLC patients
Yuru Chen, Shamileh Fouladdel, Leah Kidder, Harrison Ball, Zhaoping Qin, Abert Liu, Xu Cheng, Liwei Bao, Habib Serhan, Varun Kathawate, Laura Goo, Mary Horn, Stacy Fry, Nathan Merrill, Aaron Udager, Peter Ulintz, Angel Qin, Sofia Merajver, Sunitha Nagrath

4:55-5:10 p.m.:Location TBA
1214 - Higher risk of adverse pregnancy outcomes among racial and ethnic minority women with cancer in the United States
Duke Appiah, Julie Sang, Eric K. Broni, Zheng Shi, Catherine Kim

Posters: 2-5 p.m.

LB074 / 10 - Targeting chromatin remodeling disrupts immune suppression by pathologically activated neutrophils in cancer
Fan Yang, Yi Bao, Lanbo Xiao, Yuanyuan Qiao, Yizhi Cao, Arul M. Chinnaiyan
Section 53

1063 / 3 - CellMap: a comprehensive human single cell gene expression reference for automated cell annotation and cancer cell-of-origin analysis
Yuping Zhang, Gabriel Cruz, Hanbyul Cho, Chandan Kumar-Sinha, Rahul Mannan, Jin Chen, Xuhong Cao, Saravana M. Dhanasekaran, Arul M. Chinnaiyan
Section 46

491 / 3 - Molecular correlates of drug response to identify novel therapeutic combinations in triple-negative breast cancer
Nathan M. Merrill, Hamadi Madhi, Nathalie Vandecan, Athena Apfel, Habib Serhan, Peter J. Ulintz, Liwei Bao, Xu Cheng, Aki Morikawa, Matthew B. Soellner, Sofia D. Merajver
Section 22

449 / 10 - Small molecular inhibitors of PRC1 demonstrate potent activity in acute leukemia models
SeRa Park, Yiwu Yao, Sydney Musser, Miranda Simes, Haiqing He, Hongzhi Miao, Alyssa Winkler, Trupta Purohit, Xiaotian Zhang, Jolanta Grembecka, Tomasz Cierpicki
Section 20

406 / 25 - Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader
Yihan Liu, Abhijit Parolia, Lianchao Liu, Tongchen He, Yuanyuan Qiao, Sanjana Eyunni, Jie Luo, Zhen Wang, Arul Chinnaiyan, Ke Ding
Section 18

895 / 19 - A systemically administrated STING agonist in albumin formulation activated neutrophils for anti-cancer immunotherapy
Jinsong Tao, Hongyi Zhao, Chengyi Li, Zhongwei Liu, Hanning Wen, Qiuxia Li, Miao He, Bo Wen, Fang Ke, Wei Gao, Duxin Sun
Section 37

935 / 4 - HPV16 E6 splicing induces partial epithelial-mesenchymal transition in oropharyngeal squamous cell carcinoma
Yvonne Xinyi Lim, Min Liu, Allison Furgal, Jake McGue, Shiting Li, Bailey Garb, Timothy Frankel, Veera Baladandayuthapani, Laura Rozek, Maureen Sartor, Nisha D'Silva
Section 39

102 / 25 - Identifying predictors of liver metastasis in small cell lung cancer using gene expression profiling
George Chrisafis, Mohit Arora, Nobuyuki Takahashi, Anish Thomas
Section 4

12:55-1:10 p.m.: Location TBA
SY04-01 - Mapping the functional microproteome in cancer
John Prensner

2:30-4:30 p.m.: Location TBA
MS.CH01.01 - Innovative Approaches in Drug Discovery: Novel Leads, Degraders, and AI-Driven Solutions
Zaneta Nikolovska-Coleska, Co-chair

2:40-2:55 p.m.: Location TBA
3749 - Multi-Omic Characterization of Treatment-Naive Acute Myeloid Leukemia Reveals Subtype-Specific Features and Biomarkers of Drug Response
Yi Hsiao, Alec Chu, Yamei Deng, Chenwei Wang, Jennifer Kyle, Yongchao Dou, Jame Pino, Camilo Posso, Leanne Henry, Lijun Chen, Ginny Xiaohe Li, Mamie Lih, Yifat Geffen, Fengchao Yu, Li Ding, Gilbert S. Omenn, Chandan Kumar, Saravana M. Dhanasekaran, Elie Traer, Jefferey W. Tyner, Hui Zhang, Tao Liu, Sara S. C. Gosline, Bing Zhang, Arul M. Chinnaiyan, Alexey I. Nesvizhskii, Marcin Cieslik

4:10-4:25 p.m.: Location TBA
3825 - Divergent evolution of FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity
Sanjana Eyunni, Rahul Mannan, Yuping Zhang, Eleanor Young, Jie Luo, Jean Ching-Yi Tien, Qiuyang Zhang, Matthew Pang, Somnath Mahapatra, James George, Mustapha Jaber, Hamzah Hakkani, Sandra Carson, Abbey Todd, Noshad Hosseini, Ryan Rebernick, Xuhong Cao, Rui Wang, Fengyun Su, Rohit Mehra, Marcin Cieslik, Arul Chinnaiyan, Abhijit Parolia

Posters: 9 a.m.-Noon

LB162 / 2 - Clinically relevant humanized mouse models of metastatic prostate cancer facilitate therapeutic evaluation
Raymond J. Kostlan, John T. Phoenix, Audris Budreika, Marina G. Ferrari, Neetika Khurana, Jae Eun Choi, Kristin Juckette, Somnath Mahapatra, Brooke L. McCollum, Russell Moskal, Rahul Mannan, Yuanyuan Qiao, Donald J. Vander Griend, Arul M. Chinnaiyan, Steven Kregel
Section 54

1918 / 18 - Investigation of early dissemination in ductal carcinoma in situ patients using circulating tumor cells
Neha Nagpal, Brittany Rupp, Yan Hong, Fariba Behbod, Max Wicha, Sunitha Nagrath
Section 27

1922 / 22 - Selective microfluidic capture and molecular analysis of plasma extracellular vesicles from meningiomas
Abha Kumari, Harika Lingamarla, Mateo Gomez, Scott Smith, Kathleen McCortney, James Chandler, Craig Horbinski, David Raleigh, Adam Sonabend, Stephen Magill, Mark Youngblood, Sunitha Nagrath
Section 27

CT038 / 17 - Phase 1 study of anti-CCR8 antibody CHS-114 with and without anti-PD-1 antibody toripalimab in patients with advanced solid tumors
Francis Worden, Cristina Rodriguez, Amita Patnaik, Justin Call, A. Dimitrios Colevas, Ammar Sukari, Trisha Wise-Draper, Nabil Saba, Koho Iizuka, Hong Tang, Varun N. Kapoor, Douglas Adkins
Section 49

1829 / 15 - Potentiating antitumoral type 1 interferon immune signaling in triple-negative breast cancer (TNBC) via combination treatment of Aurora kinase B (AURKB) inhibition and radiation therapy
Kassidy M. Jungles, Caroline R. Bishop, Cydnee Wilson, Meilan Liu, Corey W. Speers, Lori Pierce, James Rae
Section 24

1499 / 4 - Combination HIF-2alpha inhibition with cholesterol biosynthesis inhibition decreases colorectal carcinoma growth
Prarthana Dalal, Boyan Hu, Rashi Singhal, Yatrik Shah
Section 13

1469 / 5 - Deciphering mechanisms of intrinsic radioresistance in breast cancer: Insights from transcriptomics and CRISPRi screens
Breanna McBean, Priyanka S. Rana, Benjamin Hauk, Anna R. Michmerhuizen, Samuel Lichtman-Mikol, Reine Abou Zeidane, Vesna Markovic, Kari Wilder-Romans, Mingfang Tao, Alan P. Boyle, Corey W. Speers
Section 12

Posters: 2-5 p.m.

3688 / 17 - Correlation between natural killer cell sensitivity and epithelial mesenchymal transition morphology: A cell morphology based screening for NK cell susceptible tumor cells
Yin Zou, Harrison Ball, Yuru Chen, Nithya Ramnath, Venkateshwar Keshamouni, Sunitha Nagrath
Section 46

2988 / 18 - Patient-survival linked TTLL12 isoform switching event sensitizes EAC cells to standard-of-care chemotherapy agents via chaperone-mediated autophagy
Yun Zhang, Rachel Israel, Bryce Vandenburg, Shari Barnett, Jean-Jack Riethoven, Jennifer Clarke, Michelle P. Lee, David A. Ntsiful, Kiran H. Lagisetty, Jules Lin, Rishindra M. Reddy, Chigozrim Ekeke, Andrew C. Chang, David Odell, Laura A. Kresty
Section 19

3001 / 2 - Highly selective and oral bioavailable PI3Kγ inhibitor for cancer immunotherapy by targeting myeloid-derived suppressor cells in tumor
Hanning Wen, Shuai Mao, Mahamadou Djibo, Chengyi Li, Jinsong Tao, Hongyi Zhao, Qiyan Wang, Weijia Zheng, Bo Wen, Wei Gao, Duxin Sun
Section 20

3540 / 16 - Proteolysis-targeting vaccines for robust combination immunotherapy of melanoma
Qiyan Wang, Ting Su, Furong Chen, Shurong Zhou, Xiang Liu, You Xu, Ri Tang, Shimiao Liao, Jordan Dailey, Guolan Xiao, Guizhi Zhu
Section 39

3545 / 21 - Enhancing anticancer immunity with SARS-CoV-2 B cell epitope-guided neoantigen nanovaccines
Chengyi Li, Fang Ke, Shuai Mao, Zera Montemayor, Mohamed Dit Mady Traore, Alejandra Duran Balsa, Mahamadou Djibo, Neha Karekar, Hanning Wen, Wei Gao, Duxin Sun
Section 39

2818 / 3 - Targeting PIKfyve sensitizes gastroenteropancreatic neuroendocrine tumor to mTOR inhibition by disrupting ferritinophagy and lipid homeostasis
Yizhi Cao, Yitong Yin, Caleb Cheng, Shannon VanAkon, Sarah Nicole Yee, Jacinda Jiali Liu, Yang Zheng, Andrej Coleski, Radha Paturu, Somnath Mahapatra, Fan Yang, Rupam Bhattacharyya, Rahul Mannan, Yuanyuan Qiao, Arul Chinnaiyan
Section 13

3596 / 21 - Risk of gastrointestinal cancer by sex and age in U.S. veterans with new-onset iron deficiency anemia
Andrew J. Read, Sarah L. Krein, Tony Van, Kennedy Dubose, Jennifer Burns, Akbar K. Waljee, Sameer D. Saini
Section 43

3559 / 2 - Racial and ethnic disparities in medication adherence between Black and Caucasian cancer survivors using oral anticancer medications: A Blinder-Oaxaca decomposition analysis
Meng-Jung Wen, Olayinka O. Shiyanbola
Section 40

3:25-3:40 p.m.: Location TBA
6371 - KLIPP: Precision targeting of fusions and amplified oncogenes using CRISPR
Huibin Yang, Radhika Suhas Hulbatte, Natalie Gratsch, Ashley Sutter, Anne Urzynicok, Mayer Cusnir, Mario Ashaka, Aadi Shiv Malhotra, Ishwarya Venkata Narayanan, Michelle Paulsen, Anna Schwendeman, Tom Wilson, Mats Ljungman

4:10-4:25 p.m.: Location TBA
6622 - Dissecting in situ states of invading glioblastoma cells using single-cell and spatial transcriptomics
Toshiro Hara

Posters: 9 a.m.-Noon

LB322 / 19 - Investigating the role of Nfe2l2 in early Alk-dependent lung adenocarcinoma tumorigenesis
Yusoo Lee, Ling Mengkun Yang, Xu Cheng, Xiangning Dong, Indrani Talukder, Micheal S. Downey, Lila Tudrick, Zhiwei Xiao, Tristan Frum, Varun Ponnusammy, Mark D. Slayton, Yatrik M. Shah, Sofia D. Merajver, Jason R. Spence, Peggy P. Hsu
Section 53

5013 / 17 - The interplay of genomic aberrations, transcriptional states, and therapeutic responses in lung cancer
Hanbyul Cho, Noshad Hosseini, Yi Hsiao, Rahul Mannan, Chandan Kumar-Sinha, Yuping Zhang, Gabriel Cruz, Yamei Deng, Taiwan Cancer Moonshot Program and Clinical Proteomic Tumor Analysis Consortium, Natalie Clark, Shankha Satpathy, Gilbert S. Omenn, Yu-Ju Chen, Michael A. Gillette, Marcin P. Cieslik, Saravana M. Dhanasekaran, Alexey I. Nesvizhskii, Arul M. Chinnaiyan
Section 45

5019 / 23 - Genomic landscape, tumor heterogeneity and immune-related post-translational regulation in cutaneous melanoma
Jianhui Gong, Gabriel Cruz, Yamei Deng, Maria Virginia Ruiz Cuevas, Chandan Kumar-Sinha, Rahul Mannan, Yi Hsiao, Francesca Petralia, Weiping Ma, Shrabanti Chowdhury, Noshad Hosseini, CPTAC Clinical Proteomic Tumor Analysis Consortium, Gilbert Omenn, Arul Chinnaiyan, Paul Harms, Raghav Jain, Jennifer Kyle, Avi Ma'ayan, Saravana Dhanasekaran, Karl Clauser, Hui Zhang, Alexey Nesvizhskii, Steven Carr, Tao Liu, Pei Wang, Marcin Cieslik
Section 45

4681 / 8 - Multiomic insights into mechanisms of androgen receptor-driven radioresistance in triple-negative breast cancer
Benjamin Hauk, Breanna McBean, Anna Michmerhuizen, Douglas Gurdak, Savannah Tidmore, Michelle Paulsen, Lynn Lerner, Connor Ward, Kassidy Jungles, Daniel Spratt, Lori Pierce, Mats Ljungman, Corey Speers
Section 33

4158 / 8 - PIKfyve inhibition drives lipogenic adaptation and reveals metabolic vulnerabilities in PDAC
Ruya Pakkan, Caleb Cheng, Jasmine Wisniewski‬‭‬, Sydney Peters, Pietro Morlacchi, Li Zhang, Yuanyuan Qiao, Costas A. Lyssiotis‬‭‬, Arul M. Chinnaiyan‬‬‬‬
Section 13

4169 / 19 - Coordination of malic enzyme 2 and the malate-aspartate shuttle supports growth and survival in triple-negative breast cancer
Mark Daniel Slayton, Jin Heon Jeon, Zackariah Farah, Abhinav Achreja, Ben Krinkel, Yi-Hsien Eu, Alyssa Rosenfeld, Kerslee Kohagen, Liwei Bao, Xu Cheng, Kerry Loomes, Deepak Nagrath, Sofia Merajver
Section 13

4173 / 23 - Compensatory interactions between tryptophan catabolism and serine metabolism highlight potential vulnerabilities in TNBC cells with dysregulated de novo serine synthesis
Jin Heon Jeon, Abhinav Achreja, Mark Slayton, Olamide Animasahun, Minal Nenwani, Fulei Wuchu, Sofia D. Merajver, Deepak Nagrath
Section 13

4979 / 26 - Effect of allostatic load (AL) and neighborhood socioeconomic status (NSES) on cancer detection and false positive rate after screening mammography
Niam Abeysiriwardena, Braelyn Wekwerth, Nathaniel Mercaldo, Sarah Bell, Ruth Carlos
Section 43

4980 / 27 - Association of allostatic load (AL) and neighborhood socioeconomic status (NSES) and breast biopsy outcomes after screening mammography
Braelyn Wekwerth, Niam Abeysiriwardena, Nathaniel Mercaldo, Sarah Bell, Ruth Carlos
Section 43

3873 / 16 - Uncovering key regulators of OSCC invasion: A pathway to novel therapeutic strategies
Guillermo Flores, Slyn Uaroon, Juan A. Raygoza Garay, Marisa R. Buchakjian
Section 2

3936 / 29 - CDK12 tumor suppressor function and therapeutic targeting in newly developed mouse models of serous ovarian cancer
Jean Ching-Yi Tien, Yali Zhai, Rong Wu, Yuping Zhang, Yu Chang, Yunhui Cheng, Abigail J. Todd, Christina Wheeler, Shuqin Li, Rahul Mannan, Caleb Cheng, Somnath Somnath Mahapatra, Xuhong Cao, Yuanyuan Qiao, Lanbo Xiao, Marcin Cieslik, Ding Ke, Kathleen R. Cho, Arul M. Chinnaiyan
Section 4

Posters: 2-5 p.m.

LB389 / 11 - R-loop formation triggers STING-mediated anti-tumor immunity following inactivation of a cyclin-dependent kinase
Yi Bao, Yu Chang, Ke Ding, Arul M. Chinnaiyan
Section 54

5603 / 13 - A precision polypharmacology approach to co-target EGFR and PI3 kinase: the power of structure-based drug design to generate therapeutic agents with versatility in multiple combination settings
Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Madeline Walker, Christopher E. Whitehead, Judith S. Sebolt-Leopold
Section 20

5384 / 12 - Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Caleb Cheng, Jasmine Wisniewski, Sydney Peters, Rüya Pakkan, Jennifer P. Morton, Pietro Morlacchi, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Section 12

5173 / 21 - Heterozygous Ppp2r1a mutations with concurrent loss of Tp53 drive invasive high-grade uterine cancer
Caitlin M. O'Connor, Kelsey Barrie, Kaitlin Zawacki, Ingrid L. Bergin, Gabrielle Hodges Onishi, Analisa DiFeo, Kathleen Cho, Thom Saunders, Goutham Narla
Section 3

5248 / 8 - Identification of a chromatin-remodeling peptide in diffuse midline glioma by immunopeptidomics
Niloofar Khairkhah, Ali Namvar, Arun Everest-Dass, Seeta Nyayapathy, Richard Jones, Julie M. Rumble, Christopher E. Whitehead, Judith S. Sebolt-Leopold, Stefanie Galban
Section 6

10:45-11:05 a.m.: Location TBA
Ferroptosis and tumor immunity
Weiping Zou

Posters: 9 a.m.-Noon

7493 / 6 - Spatially resolved insights into epithelial-stromal co-evolution in pancreatic ductal adenocarcinoma
Ahmed M. Elhossiny, Padma Kadiyala, Alexander Bray, Jamie Mills, Hannah Watkoske, Arvind Rao, Jude Okoye, Atul Deshpande, Jiaqi Shi, Elana J. Fertig, Filip Bednar, Yaqing Zhang, Eileen S. Carpenter, Timothy Frankel, Marina Pasca di Magliano
Section 46

7083 / 24 - Classical and basal like cells in donor tissues reveal phenotypic heterogeneity of pancreatic intraepithelial neoplasia
Jude O. Okoye, Rosina Carr, Ahmed M. Elhossiny, Alberto C. Olivei, Imade Williams, Lei Sun, Yaqing Zhang, Eileen S. Carpenter, Timothy L. Frankel, Marina Pasca Di Magliano
Section 29

7103 / 13 - p16 predictiveness for HPV-associated head and neck cancer in African Americans compared to Non-Hispanic Whites
Maria Christiene Lawas, Mei-Chin Hsieh, Siddhi Patil, Anju Duttargi, Aishani Kulshreshtha, Lucia Martinez Cruz, Bailey Garb, Shiting Li, Nisha D'Silva, Maureen Sartor, Laura Rozek
Section 30

6948 / 10 - A PP2A molecular glue restores heterotrimer formation for the treatment of high-grade uterine cancers
Irene Peris, Derek Taylor, George Trainor, Analisa V. DiFeo, Caitlin O'Connor, Goutham Narla
Section 24

6776 / 18 - Biological characterization of small molecule eIF4E inhibitors to assess their therapeutic potential in cancer
Rachel L. O'Rourke, Emilio L. Cárdenas, Jesse Duque, Amanda Falzetta, Jim Clauwaert, Jason Rech, John R. Prensner, Amanda L. Garner
Section 17

6667 / 22 - Dual inhibition of PIKfyve and KRAS/MAPK targets metabolic vulnerabilities of pancreatic ductal adenocarcinoma
Jasmine P. Wisniewski, Caleb Cheng, Sydney Peters, Rüya Pakkan, Pietro Morlacchi, Jennifer P. Morton, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Section 11

6698 / 21 - Inducible miRNA therapeutics: A multi-targeted strategy for treating diffuse midline gliomas
Riley Bigger, Niloofar Khairkhah, Rhea Sridhara, Hernando Lopez-Bertoni, Stefanie Galban
Section 12

7350 / 8 - Association between radioactive iodine treatment for hyperthyroidism and incident cancer
Harry D. Momo, Megan R. Haymart, Xu Shi, Alison M. Mondul
Section 41

7355 / 13 - Understanding health belief profiles and their role in medication adherence and quality of life among cancer survivors: insights from a multimethod study
Meng-Jung Wen, Olayinka O. Shiyanbola
Section 41

6501 / 12 - The SRG RAT supports in vivo human cell xenotransplantation through enhanced tumor microenvironment interactions
Caitlin M. O'Connnor, Diane Begemann, Kaitlin P. Zawacki, Kelsey Barrie, Fallon K. Noto, Grace Walton, Gabrielle H. Onishi, Jessica Durant, Taylor Branyan, Mike Schlosser, Goutham Narla
Section 3

6455 / 17 - Development of a H3K27M inducible and reversible model of diffuse midline glioma (DMG) to characterize tumor microenvironment and epigenetic memory
Niloofar Khairkhah, Sienna L. Galban, Megan Faunce, Rodrigo T. Cartaxo, Carl Koschmann, Yue Zhao, Stefanie Galban
Section 1