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Professor Diane Harper, MD, MPH, MS, of the Department of Family Medicine, has been elected to the Association of American Physicians (AAP). She was inducted at a formal ceremony on Saturday, April 22, 2023, in Chicago.
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To understand the molecular processes that influence how cancer cells pass through the blood-brain barrier, Dr. Sofia Merajver and colleagues used two microfluidic chips that mapped cancer cell migration to the brain and looked at what was happening in the blood-brain niche.
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By capturing and amplifying tiny sound waves created when X-rays heat tissues in the body, medical professionals can map the radiation dose within the body, giving them new data to guide treatments in real time. It’s a first-of-its-kind view of an interaction doctors have previously been unable to "see."
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Research from the University of Michigan Rogel Cancer Center reveals that the metabolic pathways that make a specific type of T cell function are different than previously believed. The key to this discovery lies in a new methodology developed by Hanna Hong, graduate student in immunology and first author of this study.
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The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the “undruggable” category. Now, University of Michigan Rogel Cancer Center researchers have found success with a new approach. By tapping into a cellular garbage disposal function, researchers found they could eliminate STAT5 from cell cultures and mice, setting the stage for potential development as a cancer treatment.
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As cancers grow and potentially spread to new parts of the body, they often shed cells and DNA into the blood stream. DNA can be analyzed for both the amount of DNA present and whether any potential mutations exist that may aid providers in deciding on treatments. These tests, known as liquid biopsies, have become standard practice for certain types of cancer, especially those for which there are drugs that target distinct DNA mutations. Whether liquid biopsies could help providers understand which patients may do better than others, though, is unknown.
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Undergoing emergency surgery was associated with a higher rate of complications, including death. Out of close to 5,000 patients who underwent any type of surgery for colorectal cancer, 23% had emergency surgery -- but those patients made up 63% of the deaths.
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