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Pediatric brain tumor resistance fueled by unique metabolism

Diffuse intrinsic pontine glioma, or DIPG, is the most aggressive pediatric brain tumor and incredibly difficult to treat since surgery isn’t feasible and recurrence is likely after radiation. This research may provide some insight.

Early warning sign of major immunotherapy complication could be white blood cell "nets"

Research findings show that a process called NETosis, in which neutrophils eject their DNA to create webs, may contribute to the development of cytokine release syndrome (CRS), a potentially life-threatening hyper-activation of the immune system.

Rogel Cancer Center expands leadership roles to enhance DEI, health equity

The University of Michigan Rogel Cancer Center has created two new associate director positions to further advance cancer health equity for patients and communities across the State of Michigan and inclusive excellence for the center’s research workforce and leadership teams. Erika Newman, M.D., will serve as associate director for cancer health equity, and Simpa Salami, M.D., M.P.H., will be associate director for research workforce and leadership development.

Head and neck cancer can be detected with urine based test

Researchers from the University of Michigan Health Rogel Cancer Center have created a urine-based test that detects pieces of DNA fragments released by head and neck tumors. The test could potentially facilitate early detection of this cancer type, which currently does not have a reliable screening method.

Metabolite GPT tells cells whether to repair DNA

Metabolites called nucleotides are the building blocks of DNA and can impact cancer’s sensitivity or resistance to chemotherapy and radiation in brain cancer. Recent findings show how a specific nucleotide metabolite, called GTP, controls responses to radiation and chemotherapy in an unexpected way.

Drug-chemo combo increases breast cancer treatment efficacy

Preclinical models show that combining an inhibitor of a metabolic pathway with chemotherapy could improve outcomes in triple-negative breast cancer brain metastases.

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Rogel ranked No. 1 in Michigan, among best cancer centers in nation by U.S. News & World Report

The University of Michigan Health Rogel Cancer Center is once again the highest rated center for cancer care in Michigan, according to U.S. News & World Report’s Best Hospitals rankings. Rogel ranked No. 34 in the nation, and is the only hospital ranked for cancer care in Michigan.

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