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Shared Resources

Providing Expert Support for Specialized Research

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Our Shared Resources provides state-of-the-art services and technologies that deliver empowering and cost-effective support to our clinical, population and basic science investigators. Get the latest news about our resources.

Access Shared Resources’ Specialized Services. Contact information is included in each of the areas of expertise.

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Cancer Data Science [CDS]
CDS provides assistance to Rogel Cancer Center investigators in all quantitative aspects of cancer research. Visit webpage.

Director: Veera Baladandayuthapani, Ph.D.
Assistant Co-Director for Bioinformatics and Laboratory Sciences: Gen Li, Ph.D.
Assistant Co-Director for Population and Clinical Sciences: Menggang Yu, Ph.D.

Program Manager: Erik Roys, M.S.
Assistant: Lauren Detzler
Location: Washington Heights, M2030-26 SPH II
Phone: 734-936-0458

Cell and Tissue Imaging [CTI] (aka: BRCF Microscopy)
CTI is a centralized operation including more than 3,000 square feet focusing mainly on studies of cell and tissue morphology and ultrastructure. Visit webpage.

Managing Director: Jennifer Peters, Ph.D.
Faculty Director: Gary Luker, M.D.
Locations: BSRB A830 | Med Sci II Rm 5631 | NCRC B20-53S
Phone: 734-936-4912

Epigenetics and Epigenomics [EE] (developing)
EE provides expertise & services for analysis of gene regulation for genome-wide (epigenomics) & locus-specific (epigenetics) studies in tumors and cancer tissues for DNA & histone modifications and chromatin accessibility/conformation. Visit the webpage.

Faculty Director: Dana Dolinoy, Ph.D.
Managing Director: Claudia Lalancette, Ph.D.
Phone: 734-764-2223
Location: MSRB 2, Room C568

Experimental Irradiation [EI]
EI provides extensive irradiation services to support research studies. Visit webpage.

Director: Meredith Morgan, Ph.D.
Manager: David Karnak, Ph.D.
Locations: 4310 Med Sci I, 3504E ARF Med Sci I, D714 BSRB, B026-G11N NCRC

Flow Cytometry [FLOW]
The FLOW provides support for clinical and basic science research investigators at Rogel, well as surrounding biotech institutions using state-of-the-art flow cytometry analysis and cell sorting. View the webpage.

Director: Thomas Moore, Ph.D.
Manager: David Adams, MsEd
Locations: C574 MSRB II | BSRB A701 | NCRC Bldg 20, 134D
Phone: 734-647-3216

Health Communications [HC]
HC provides communications services for research studies requiring targeted and tailored interventions that inform health decisions. View the web page

Director: Lawrence An, M.D.
Manager: Elizabeth Hershey
Location: NCRC, Bldg 16, Ground Floor
Phone: 734-763-6099

Immune Monitoring [IM]
IM provides immunologic and biological support for ongoing research projects and clinical trials at Rogel Cancer Center and the biomedical community at the University of Michigan. View the webpage.

Co-Directors: Fei Wen, Ph.D.
Maria Castro, Ph.D.

Manager, Immune Monitoring: Joel Whitfield
Manager, CyTOF: Trang Hoang

Locations: 4725 Med Sci 2 (Immune Assays); NCRC B028-G019E (CyTOF)

Liquid Biopsy [LB] (developing)
LB provides state-of-the-art engineering solutions and platforms to analyze liquid biopsies, including cell-free nucleic acid, circulating tumor cells, immune cells, and extracellular vesicles. View the webpage

Directors: Sunitha Nagrath, Ph.D.
Simpa Salami, M.D.

Pharmacokinetics [PK]
PK facilitates both preclinical and clinical pharmacokinetic-based cancer research efforts through a range of services. View the webpage.

Director: Duxin Sun, Ph.D.
Co-Director: Amit Pai, PharmD.

Manager: Bo Wen
Location: NCRC, Bldg 520, 3400M
Phone: 734-615-3470

Preclinical Molecular Imaging [PMI]
PMI uses the latest imaging instruments, in a state-of-the-art facility, for expert computational analysis. Visit the webpage.

Director: Brian Ross, Ph.D.
Manager: Amanda Fair
Phone: 734-615-3009

Locations: BSRB D200 and NCRC B026 Rm 335C (IVIS only)

Proteomics Resource Facility [PRF]
Mass spectrometry-based PRF assists researchers in designing proteomic experiment, maintain state-of-the-art instrumentation, provide technical expertise and bioinformatic support during both discovery and validation phases of proteomic experiments. View the webpage.

Director: Alexey Nesvizhskii, Ph.D.
Manager: Venkatesha Basrur, Ph.D.
Location: Rm 3554/3556, MSRB
Phone: 734-615-5722

Single Cell Spatial Analysis [SCSA]
SCA provides expertise to basic and clinical sciences research investigators at Rogel Cancer Center and surrounding institutions. View the webpage.

Co-Directors: Evan T. Keller, D.V.M., Ph.D.
Thomas Wilson, M.D., Ph.D.
Managing Director: Olivia Koues, Ph.D.
Location: NCRC, Bldg 20, 334W-D
Email: [email protected]

Structure and Drug Screening [SDS]
SDS supports and enhances cancer research projects through collaborative efforts. View the webpage.

Co-directors: Andrew Alt, Ph.D., Center for Chemical Genomics
Janet Smith, Ph.D., Center for Structural Biology
Manager: Jeanne Stuckey, Ph.D., Center for Structural Biology
Locations: Life Sciences Institute, 210 Washtenaw, Room 3358; College of Pharmacy, 4562 CC Little, 428 Church St.
Phone: 734-647-8098

Tissue and Molecular Pathology [TMP]
TMP consists of three distinct, yet complementary services relating to the procurement and evaluation of tissue for research: Tissue Procurement, Histology, and Molecular Pathology. View the webpage.

Co-Directors: Steven Hrycaj, Ph.D.
Aaron Udager, M.D., Ph.D.
Managing Director: Dafydd Thomas, M.D., Ph.D.
General questions: Thomas Giordano, Ph.D.
Phone: 734-647-3261

Transgenic Animal Models [TAM]
TAM provides complex technology solutions. Working in collaboration with the Bacterial Artificial Chromosome Recombineering Core, we provide effective tools for successful research. View the webpage.

Director: Zachary Freeman, D.V.M, Ph.D.
Location: 2570 MSRB II
Phone: 734-647-2910

Important Resources

Logo for the Instrumental resource newsletter for shared resources

 

LEADERSHIP UPDATES | NEWS AND UPDATES | MEET THE EXPERT | CONTACT OUR TEAM

 

Leadership Updates

New Shared Resources Leaders

Sethu Pitchiaya, Ph.D., assistant professor of urology and pathology, recently joined the Rogel leadership team as the assistant director for Shared Resources. In this role, Dr. Pitchiaya will work under the guidance of Evan Keller, D.V.M, Ph.D., associate director for Shared Resources, to promote Rogel SRs and their services and to advance initiatives that further enhance the utility, value, innovation and impact of our SRs.

Menggang Yu, Ph.D., has joined the Cancer Data Science Shared Resource (CDS-SR) as assistant co-director for Population and Clinical Sciences. Dr. Yu previously served as the faculty director of the Biostatistics Shared Resouce for the Carbone Cancer Center at the University of Wisconsin Madison and was the director of the Biostatistics and Bioinformatics Core of the UW Head and Neck Specialized Program of Research Excellence (SPORE). He is an expert in the areas of risk prediction, clinical biostatistics and treatment selection. In collaboration with CDS-SR director, Veera Baladandayuthapani, Ph.D., and assistant co-director for Bioinformatics and Laboratory Sciences, Gen Li, Ph.D., Dr. Yu will lead research initiatives in cancer biostatistics and develop biostatistical tools for population and clinical sciences.

Aaron Udager, MD, Ph.D., has joined as co-director of the Tissue and Molecular Pathology Shared Resource (TMP-SR). Dr. Udager is a fellowship-trained surgical pathologist with broad clinical expertise in diagnostic pathology and research expertise conducting molecular pathology studies. The TMP-SR leadership team also includes co-director, Steven Hrycaj, Ph.D., who leads the Histology and Immunohistochemistry Service.

Dr. Udager succeeds Thomas Giordano, M.D., Ph.D., who has been involved with the TMP-SR since 1996 and has served as director since 2002. We are deeply grateful to Dr. Giordano for his decades of service.

 

News and Updates

New recharge rates for CDS-SR

CDS-SR has adopted a recharge rate of $110 per hour for projects requiring less than 200 person hours. Projects requiring more than 200 hours will continue under the previously established effort-based model.

Supplemental funding for Discovery Award grantees toward use of CDS-SR

Additional funds, up to $10K, are available for Rogel Cancer Center Discovery Awardees who plan to use the CDS-SR. Investigators should consult with the SR to determine the level of support needed for the project and to receive the requisite Letter of Support to be submitted with the application. For more information on the current Discovery Award RFA and to submit an application, please visit the UMMS InfoReady website.

Informatics Technology for Cancer Research Training Network (ITN) workshop April 8 - 9 at NCRC

Rogel and the ITN are hosting a training event that focuses on the latest informatics tools and techniques while exploring these courses:

  • Introduction to Reproducibility
  • Intermediate and Advanced Reproducibility
  • Analyzing Clinical Data
  • Choosing Genomics Tools
  • Spatial Transcriptomics

The workshop will conclude with an introduction to U-M resources by representatives from the CDS-SR and Single Cell Spatial Analysis Program.

The workshop is free of charge and lunch is provided. Register now for one or both days; space is limited to 40 attendees per day with some spaces reserved for external attendees. A limited number of travel awards are available by applying directly to the ITN. Travel scholarships are reserved for external attendees, which may include individuals from U-M campuses outside of Ann Arbor.

Transgenic animal models hosts educational series

The Transgenic Animal Model Shared Resource (TAM-SR) is hosting the Make Your Model Education Series. Join for a complimentary lunch and an opportunity to learn from Eden Dulka, microinjectionist and cryopreservation manager for the TAM-SR. Register to attend any, or all, of the following sessions:

  • Identifying your model: Engineering what you need.
    Feb. 27 I Noon- 1 p.m.
  • Making a mouse: How is your mouse technically created?
    Mar. 27 I Noon - 1 p.m.
  • QC + genotyping: Validate what you made is what you think it is!
    Apr. 17 I Noon - 1 p.m.

 

Meet the Expert: Cancer Data Science

Nick Lesniak, Ph.D..
Bioinformatician-Computational Biologist Senior

What is your area of expertise?
Microbiome, single cell RNA sequencing analysis, and multiplex imaging analysis.

What types of analyses do you run most frequently?
Identifying relationship between outcomes and phenotyped cell clusters.

What inspired you to pursue this career path?
I look to use my background in visual communication and bioinformatics to help scientists and physicians uncover and share the story of their data to advance our understanding and management of cancer.

What do you see as the most exciting developments in your field right now?
Spatial methods and throughput are improving our ability to elucidate the critical interactions occurring in tumor microenvironments.

What book or podcast would you most recommend to a colleague?
I would recommend Medical Apartheid. It is important to know the ways Black Americans have been mistreated by science so we can understand people's mistrust and do better to ensure we are not repeating past injustices.

 

Contact our Team

If you have questions about Shared Resources services at the University of Michigan Rogel Cancer Center, please contact us for more information. Fill out our feedback form and help us improve our services!

Associate Director: Evan Keller, DVM, Ph.D.

Assistant Director: Sethu Pitchiaya, Ph.D.

Research Administrator: Kimberly Zuhlke

Location: 6216 Rogel Cancer Center
Phone: 734-647-7222

 

Keep up-to-date on Shared Resources:

Watch past seminars on Dropbox!

SDS-SR: Make it one of your first stops on the road to developing a new cancer therapeutic
Rogel Structure and Drug Screening Shared Resource, Jeanne Stuckey, Ph.D. presented on June 9, 2022

Positron emission tomography: molecular imaging in the age of personalized medicine
Preclinical Molecular Imaging Shared Resource, Peter J.H. Scott, Ph.D. presented on April 7, 2022

Multiplex immunofluorescence and whole slide imaging: understanding complex phenotypes and microenvironments through multispectral analysis
Tissue and Molecular Pathology, Paul Harms, M.D., Ph.D., co-director
Presented by Timothy Frankel, M.D. on March 3, 2022.

The ins and outs of PK-PD.
Pharmacokinetics
Presented by Amit Pai, PharmD. on February 3, 2022

The BRCF Microscopy Core: Current Technologies and Future Plans
BRCF Microscopy
Presented by Jennifer Peters, Ph.D. on December 2

Design and analysis of quantitative proteomics experiments
Proteomics Resource Facility
Presented by Felipe da Veiga Leprevost, Ph.D. and Sarah Haynes, Ph.D. on November 4

Introduction to CyTOF: 40-parameter analysis of single cells and tissue sections
Immune Monitoring Shared Resource
Presented by Luke Bugada on October 7, 2021